Low-Intensity Focused Ultrasound-Augmented Multifunctional Nanoparticles for Integrating Ultrasound Imaging and Synergistic Therapy of Metastatic Breast Cancer

Non-thermal high-intensity focused ultrasound for breast cancer therapy

Preclinical ultrasound image-guided high intensity focused ultrasound robot system for breast cancer therapy

Background/introduction Ultrasound imaging provides real-time feedback for highly accurate positioning and dosing control. In addition, spatial restriction of high-intensity focused ultrasound (HIFU) transducer position in the ultrasound image-guided system is less than that in the case of MRI-guided system. Therefore, wider beam approaching path can be used in the ultrasound image-guided syste...

HematoPorphyrin Monomethyl Ether polymer contrast agent for ultrasound/photoacoustic dual-modality imaging-guided synergistic high intensity focused ultrasound (HIFU) therapy

This study is to prepare a hematoporphyrin monomethyl ether (HMME)-loaded poly(lactic-co-glycolic acid) (PLGA) microcapsules (HMME/PLGA), which could not only function as efficient contrast agent for ultrasound (US)/photoacoustic (PA) imaging, but also as a synergistic agent for high intensity focused ultrasound (HIFU) ablation. Sonosensitizer HMME nanoparticles were integrated into PLGA microc...

Noninvasive Treatment of Breast Cancer Using High-Intensity Focused Ultrasound

Breast conserving surgery is a standard procedure for breast cancer since 1970. Now noninvasive therapy with few complications is preferred. High-intensity focused ultrasound (HIFU) has been developed to ablate solid tumor or cancer noninvasively. Its clinical outcome on breast cancer in China and Europe as well as the induced vascular destruction and immune response are summarized. In summary,...

Clinical Application of High-intensity Focused Ultrasound in Cancer Therapy

The treatment of cancer is an important issue in both developing and developed countries. Clinical use of ultrasound in cancer is not only for the diagnosis but also for the treatment. Focused ultrasound surgery (FUS) is a noninvasive technique. By using the combination of high-intensity focused ultrasound (HIFU) and imaging method, FUS has the potential to ablate tumor lesions precisely. The m...